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myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca homeostasis in a murinemodel of HFpEF

Frontiers of Medicine doi: 10.1007/s11684-023-0983-0

Abstract: myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca homeostasis in a murinemodel of HFpEF

Keywords： mitochondrial fission Ca     Berberine alleviates myocardial     murine model HFpEF    

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Gene and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft host

Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 309-315 doi: 10.1007/s11684-009-0043-4

Abstract: In the present study, we first detected the expression of PAR-1, 2 protein and mRNA in a murine model

Keywords： graft vs host disease     proteinase-activated receptor     murine model     hematopoietic stem cell transplantation    

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4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 20-25 doi: 10.1007/s11684-009-0006-9

Abstract: sequence was constructed, and the plasmid was transfected into baby hamster kidney (BHK) cells and murine

Keywords： 4-1BB ligand     tumor immunotherapy     tumor microenvironment    

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Establishment and drug sensitivity evaluation of murine ascites hepatocarcinoma cell line with high lymphatic

Hongying ZHANG, Jianwu TANG, Wenting ZHU, Chunxiu HU, Guowang XU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 119-129 doi: 10.1007/s11684-009-0022-9

Abstract: In order to provide a sensitive cell line model for investigating the mechanisms underlying the lymphaticmetastasis of tumors and the effect of medicine against cells, a new murine ascites hepatocarcinomaMurine ascites hepatocarcinoma cell strain with low lymphatic metastatic potential (Hca-P) was subcutaneouslyCurcumin had significant growth inhibiting effect on both murine ascites and human hepatocarcinoma cellHca-P/L is a novel sensitive cell line model for investigating the mechanisms underlying tumor lymphatic

Keywords： murine ascites hepatocarcinoma cell line     metastasis     curcumin     drug sensitivity    

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Blockage of receptor-interacting protein 2 expression by small interfering RNA in murine macrophages

LIU Hongchun, CAO Zhongwei, JIN Jianjun, WANG Jiyao

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 166-170 doi: 10.1007/s11684-008-0030-1

Abstract: Murine Rip2 small interfering RNA (siRNA) plasmids were constructed and transfected into macrophage and
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Immunotherapeutic effects on murine pancreatic carcinoma by β-elemene combined with dendritic cells modified

TAN Guang, WANG Zhongyu, CHE Luanqing, YIN Shuo

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 41-45 doi: 10.1007/s11684-007-0008-4

Abstract: The dendritic cell vaccine is a treatment vaccine with potent clinical applications. Functional cytokines can enhance dendritic cell anti-tumor immune responses. This experiment was conducted to study the effects of bone marrow-deriv

Keywords： Functional     experiment     anti-tumor     dendritic     clinical    

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Investigation on the mechanism of ginsenoside Rg3 in treating murine primary mammary tumor

Hongbo TANG MD, Zirong YE MM, Yuping REN MD, Zhanyong ZHU MD, Yiping WU MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 421-425 doi: 10.1007/s11684-009-0078-6

Abstract: A murine primary mammary tumor model was established to investigate the treatment with ginsenosides Rg3Ginsenoside Rg3 can play an antitumor role in primary mammary tumor model by inhibiting angiogenesis,

Keywords： ginsenoside Rg3     mammary tumor     mice    

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Lentivector-mediated RNAi efficiently downregulates expression of murine cdk4 gene

Feng JIANG PhD , Xuezhen WANG PhD , Zheng XUE MD , Suming ZHANG PhD , Siyu FANG BM , Min ZHANG MD, PhD ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 287-291 doi: 10.1007/s11684-009-0050-5

Abstract: neurodegenerative diseases, lentiviral-delivered RNA interference (RNAi) was used to silence the expression of the murineLentivector-mediated RNAi could efficiently down-regulate the expression of the murine cdk4 gene , which

Keywords： cyclin-dependent kinase 4     RNA interference     plasmid     lentiviral vector    

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Standard model of knowledge representation

Wensheng YIN

Frontiers of Mechanical Engineering 2016, Volume 11, Issue 3,   Pages 275-288 doi: 10.1007/s11465-016-0372-3

Abstract: methods include predicate logic, semantic network, computer programming language, database, mathematical modelintrinsic link between various knowledge representation methods, a unified knowledge representation modelAccording to ontology, system theory, and control theory, a standard model of knowledge representationThe model is composed of input, processing, and output.In addition, the standard model of knowledge representation provides a way to solve problems of non-precision

Keywords： knowledge representation     standard model     ontology     system theory     control theory     multidimensional representation    

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State of the Art of Compartment Fire Modeling

Zheng Xin,Yuan Hongyong

Strategic Study of CAE 2004, Volume 6, Issue 3,   Pages 68-74

Abstract: The relevant underlying physical assumptions are presented first and the conventional model performance

Keywords： compartment     field model     zone model     network model     FZN (field     zone and network) model     empirical model    

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Elevated temperature creep model of parallel wire strands

Frontiers of Structural and Civil Engineering   Pages 1060-1071 doi: 10.1007/s11709-023-0981-y

Abstract: analyze their creep behavior, this study experimentally investigated the elevated temperature creep modelThe parameters in the general empirical formula, the Bailey–Norton model, and the composite time-hardeningmodel were fitted based on the experimental results.By evaluating the accuracy and form of the models, the composite time-hardening model, which can simultaneously

Keywords： parallel wire strands     experimental study     elevated temperature creep model    

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Impact of crude distillation unit model accuracy on refinery production planning

Gang FU, Pedro A. Castillo CASTILLO, Vladimir MAHALEC

Frontiers of Engineering Management 2018, Volume 5, Issue 2,   Pages 195-201 doi: 10.15302/J-FEM-2017052

Abstract: In this work, we examine the impact of crude distillation unit (CDU) model errors on the results of refinery-wideWe compare the swing cut+ bias CDU model with a recently developed hybrid CDU model (Fu et al., 2016)The hybrid CDU model computes material and energy balances, as well as product true boiling point (TBPCase studies of optimal operation computed using a planning model that is based on the swing cut+ biasCDU model and using a planning model that incorporates the hybrid CDU model are presented.

Keywords： impact of model accuracy on production planning     swing cut+ bias CDU model     hybrid CDU model     refinery feedstock    

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Test-driven verification/validation of model transformations

László LENGYEL,Hassan CHARAF

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 2,   Pages 85-97 doi: 10.1631/FITEE.1400111

Abstract: Why is it important to verify/validate model transformations?Verified/validated model transformations make it possible to ensure certain properties of the generatedFor example, a verified/validated model transformation can ensure the preservation of certain propertiesduring the model-to-model transformation.of a novel test-driven method for verifying/validating model transformations.

Keywords： Graph rewriting based model transformations     Verification/validation     Test-driven verification    

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Digital twin-assisted gearbox dynamic model updating toward fault diagnosis

Frontiers of Mechanical Engineering 2023, Volume 18, Issue 2, doi: 10.1007/s11465-023-0748-0

Abstract: One of the core challenges of intelligent fault diagnosis is that the diagnosis model requires numerousGenerating training data using a virtual model is a potential solution for addressing such a problem,and the construction of a high-fidelity virtual model is fundamental and critical for data generationIn this study, a digital twin-assisted dynamic model updating method for fault diagnosis is thus proposedhelical gearbox; the virtual data generated by this model can be used for gear fault diagnosis.

Keywords： digital twin     gearbox     model construction     model updating     physical–virtual interaction    

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Title Author Date Type Operation

myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca homeostasis in a murinemodel of HFpEF

Journal Article

Gene and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft host

Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,

Journal Article

4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Journal Article

Establishment and drug sensitivity evaluation of murine ascites hepatocarcinoma cell line with high lymphatic

Hongying ZHANG, Jianwu TANG, Wenting ZHU, Chunxiu HU, Guowang XU

Journal Article

Blockage of receptor-interacting protein 2 expression by small interfering RNA in murine macrophages

LIU Hongchun, CAO Zhongwei, JIN Jianjun, WANG Jiyao

Journal Article

Immunotherapeutic effects on murine pancreatic carcinoma by β-elemene combined with dendritic cells modified

TAN Guang, WANG Zhongyu, CHE Luanqing, YIN Shuo

Journal Article

Investigation on the mechanism of ginsenoside Rg3 in treating murine primary mammary tumor

Hongbo TANG MD, Zirong YE MM, Yuping REN MD, Zhanyong ZHU MD, Yiping WU MD,

Journal Article

Lentivector-mediated RNAi efficiently downregulates expression of murine cdk4 gene

Feng JIANG PhD , Xuezhen WANG PhD , Zheng XUE MD , Suming ZHANG PhD , Siyu FANG BM , Min ZHANG MD, PhD ,

Journal Article

Standard model of knowledge representation

Wensheng YIN

Journal Article

Zhang Zhengyan: Pre Training Language Model Integrating Knowledge (2020-4-3)

18 Apr 2022

Conference Videos

State of the Art of Compartment Fire Modeling

Zheng Xin,Yuan Hongyong

Journal Article

Elevated temperature creep model of parallel wire strands

Journal Article

Impact of crude distillation unit model accuracy on refinery production planning

Gang FU, Pedro A. Castillo CASTILLO, Vladimir MAHALEC

Journal Article

Test-driven verification/validation of model transformations

László LENGYEL,Hassan CHARAF

Journal Article

Digital twin-assisted gearbox dynamic model updating toward fault diagnosis

Journal Article